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Thyrotoxicosis- What do you need to know and doctors don't have time to tell you?

 
 

When thyrotoxicosis is suspected, the diagnosis should be confirmed by measurement of thyroid stimulating hormone and free thyroxine in the serum, which are usually present in low and high concentrations respectively.

The concentration of thyroid stimulating hormone may, however, be normal or increased if the cause of thyrotoxicosis is either a pituitary adenoma secreting thyroid stimulating hormone or resistance to thyroid hormone.

In the latter case the patient is clinically euthyroid. Estimation of total thyroxine concentration is not useful and may be misleading as various factors, including pregnancy, cirrhosis of the liver, and opiate drugs, alter the binding of thyroxine to thyroxine binding globulin.

 

 

When the concentration of thyroid stimulating hormone is low but that of thyroxine normal, serum concentration of free triiodothyronine should be measured to diagnose triiodothyronine (T3) toxicosis. Thyroxine (T4) toxicosis (raised concentration of free thyroxine, normal concentration of free triiodothyronine), which is unusual, may occur with high iodine intake, treatment with amiodarone, severe intercurrent illness, or starvation. Finally, euthyroid patients with Graves' ophthalmopathy, severe non-thyroidal illness, large goitres, or those who have had recent treatment for thyrotoxicosis may have a suppressed concentration of thyroid stimulating hormone.

Medical treatment

Antithyroid drugs: carbimazole, methimazole and propylthiouracil constitute the thionamide group of antithyroid drugs. They inhibit the organification of iodide and coupling of iodothyronines, thus reducing production of triiodothyronine and thyroxine. Propylthiouracil also inhibits the peripheral conversion of thyroxine to triiodothyronine. In addition to blocking thyroid hormone biosynthesis, these drugs also lower concentrations of thyroid stimulating hormone receptor antibodies and increase acitivity of suppressor T cells, which suggests that they have immunosuppressive effects.3 Carbimazole is given once daily, which makes it the drug of first choice. Once patients are taking a maintenance dose, serum concentrations of free thyroxine and thyroid stimulating hormone are measured every three months.

The duration of antithyroid treatment has been much studied and debated (6-24 months), but is usually 18 months.4

Blockers

These are useful adjunctive agents and ameliorate some of the clinical features, such as tremor, palpitations, and anxiety. Propranolol (120-240 mg/day) is the most commonly used b blocker, although any could be used. Once a euthyroid state has been reached, the b blocker is discontinued.

Summary  for Thyrotoxicosis/ Hyperthyroidism

  • Graves' disease is the commonest cause of thyrotoxicosis, with a strong female:male preponderance
  • It is an autoimmune disease: the thyrotoxicosis is caused by the presence of thyroid stimulating antibodies
  • Eyes and skin are not uncommonly affected
  • Initial treatment is with carbimazole or propylthiouracil, together with the use of a blocker for the first 4-6 weeks

Patients should be warned of the side effects of antithyroid drugs. For more information about Hyperthyroidism check the following:

Other Alternative Methods for Hyperthyroidism

50 Hyperthyroidism Symptoms

5 Alternative Treatments of Hyperthyroidism

Acupuncture

20 Possible Triggers for Hyperthyroidism/ Graves' Disease

Graves' Disease Diet

Graves' Disease Book

More...................

 

 I believe that once your symptoms are under control and your test are in normal range your eyes will start to improve. So besides treating the symptoms I would recommend treating the cause of Graves’ Disease as well.

Svetla Bankova

CTACC, MBA in Counseling Psychology,

former Graves' Disease patient

About the author: Svetla Bankova is an author of "Life Manual for Graves' Disease and Hyperthyroidism"- a book, based not only  on her experience as a former Graves' Disease patient but also her research as a psychologist. This is  only book that explains step by step how and why Graves' Disease came to your life, the cause and specific steps for alternative treatment of Graves' disease. The book provides also specific steps how to treat Thyroid Eye Disease, numerous practical exercises, recipes for herbal compresses, how to use flax seed oil and many other supplements that will improve your eyes tremendously.

To get your copy today and start taking care  of your Thyroid Eye Disease click here:

 

 

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