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Good news about pregnancy and Graves' Disease and Hyperthyroidism. Male fertility problems.

In 2002, G.E. Krassas Department of Endocrinology & Metabolism "Panagia", Thessaloniki, Greece & P. Perros Endocrine Unit, Freeman Hospital , Newcastle upon Tyne U.K.,  measured progesterone levels, a fertility parameter, in the middle of the luteal phase of the cycle in 74 women of reproductive age, 37 of whom had Graves' disease and 37 of whom were euthyroid controls matched for age and weight. They  found that progesterone levels were decreased before treatment in comparison with controls and were unrestored 4 months after carbimazole therapy. It is not clear though if these patients became euthyroid after 4 months of medication. They also found:

Hyperthyroidism appears to cause sperm abnormalities (mainly reduction in motility), which reverse after restoration of euthyroidism.

Radioiodine therapy for thyroid cancer may cause transient reductions in sperm count and motility, but there appears to be little risk of permanent effects provided that the cumulative dose is less than 14 GBq.

 

The incidences of stillbirth, preterm birth, low birth weight, congenital malformation, and death during the first year of life are similar between pregnancies conceived before and after 131I therapy (i.e radiation) for thyroid cancer. Pregnancy should be avoided for at least one year after the 131I. Therapeutic administration of 131I should be followed by immediate cessation of breastfeeding. 

However, N. AMINO, R. KURO, 0. TANIZAWA,F. TANAKA, C. HAYASHI, K. KOTANI,t M. KAWASHIMA, K. MIYAI & Y. KUMAHARA+ The Central Laboratory for Clinical Investigation, and The Department of Obstetrics and Gynecology, and The Department of Medicine and Geriatrics, Osaka University Hospital, and Osaka Laboratory, Japan investigated the changes of serum anti-thyroid antibodies during and after pregnancy in autoimmune thyroid diseases and actually this research really made me happy. Why?

All the patients investigated for the purpose of this report had either Graves’ Disease or autoimmune thyroditis. Some were on thyroid medication, or had subtotal thyroidectomy, before the pregnancy, some of them neither one- i.e the disease was not treated by any means. During the pregnancy most of them wasn’t necessary to be treated at all, some of them though were on thyroid medication.

All of them became euthyroid during pregnancy. I.e their hormones were fixed by the pregnancy. After the delivery pretty much none of them needed any treatment- some of them had transient thyrotoxicosis, some became euthyroid and just 2 had their thyrotoxicosis aggravated.

Bottom line: 1. It is possible to get pregnant, even with thyroid disease like Graves’. 2. It is possible to stay pregnant and have successful pregnancy. 3. Most probably the pregnancy can “cure” your Graves’ disease. 4. All the babies were healthy. 5. Find a doctor, who is willing to work with you to help you get and stay pregnant.

See by yourself- click here to view the complete report (it's a PDF file, so it may take a minute to download)

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